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Brain images of those reporting long-term use of steroids were compared with images from non-users. Those who said they had used steroids at least once a month showed higher activity-related volumes in the caudate, putamen and amygdala. The authors also found that for those who claimed to have used steroids "at least monthly," there was greater activity-related volumes in the prefrontal regions. So, while it seems that using steroids for the purpose of training can result in increases in brain volume, scientists also recommend to limit their use in older adults. "More research is needed to determine whether this is consistent with the general notion that people with reduced motivation have larger volumes of brain areas involved in attention and impulse control," wrote the authors. The authors wrote that their study "does suggest the possible value of providing a positive feedback system or encouraging healthy exercise in individuals in need of exercise." Explore further: Injecting steroids could lead to brain damage, say scientists (Update) More information: E. E. E. Vanneman et al. The Effects of Long- Term Steroids Use on Cognition and Brain Structure in Older Adults, Frontiers in Cellular Neuroscience (2017). DOI: 10.3389/fncel.2017.01130 Abstract There is growing interest in the potential negative impact of long-term use of steroids on the brain. This work aimed to identify the impact of long-term steroids use on cognition and brain structure. Forty-six men, aged 42–79 (mean ± SE, 54.2 ± 11.9 years), participated in this study. They completed four memory and personality measurements: the Trail Making Test (TMT), the Stroop-Test, the Finger Tapping Test and the Short-Term Memory Battery. During their participation in the study, they were asked to walk up and down a stairs for 60 seconds in a counterclockwise direction and to count the number of steps they took for each footstep to the left or the right. We asked the participants to report any side effects they had experienced during the study. Subjects were asked about past and current medical and psychiatric conditions, including hormone replacement therapy, anxiety, substance abuse and depression, as well as any history of previous steroid use. They also provided demographic information, including age, educational level, marital status, race and physical activity level. A total of 867 subjects could be included in each analysis. During the first week of the study, subjects were asked to remain at the research lab for 1 hour at least once a week for the next 14 weeks Related Article: